By Jeffrey L Cummings, Serge Gauthier

Given the improvement of recent healing innovations and items, Serge Gauthier and Jeffrey Cummings have compiled a listing of up to date themes for you to be of curiosity essentially to neurologists targeting Alzheimer's ailment, and likewise to psychiatrists and geriatricians. The members, all revered of their subspecialties, have written up to date, comprehensively referenced chapters which should offer information in addition to stimulate dialogue on the place present remedy is heading.

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Extra resources for Alzheimer's disease and related disorders annual, 2002

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94:739–750. 52. Cecconi F, Alvarez-Bolado G, Meyer BI et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 1998; 94:727–737. 53. Troy CM, Stefanis L, Prochiantz A et al. The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc Natl Acad Sci USA 1996; 93:5635–5640.

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the SM checkpoint and causes apoptosis in neurons. J Biol Chem 2000; 275:8929–8935. 98. Giovanni A, Wirtz-Brugger F, Keramaris E et al. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death. J Biol Chem 1999; 274:19011– 19016. 99. Younkin SG. Amyloid beta vaccination: reduced plaques and improved cognition. Nat Med 2001; 7:18–19. 100. Vandermeeren M, Geraerts M, Pype S et al.

51,52 Secondly, it is possible that there is cross-talk between the pathways with one activating the other. Finally, these data are all derived from acute studies on model systems in which the only variable is the exogenous addition of Aβ. The disease process in man or even in transgenic animal models is much more gradual and in addition to the accumulation of Aβ, there is elevation of a variety of cytokines Alzheimers CH02 28 17/6/02 2:36 pm Page 28 Apoptosis and its role in Alzheimer’s Disease including IL-1β, the production and accumulation of free radicals and a complex series of interactions between neurons and glia.

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