By Jeffrey L Cummings, Serge Gauthier
The editors and participants tackle modern themes during this sector via comprehensively referenced chapters, in response to medical adventure and clinical proof designed to stimulate dialogue of the place present remedy is heading.
content material: e-book conceal; name; Contents; members; Preface; Amyloid processing in Alzheimer's affliction mind; Cerebral amyloid (congophilic) angiopathy; scientific use of neuroimaging within the overview of dementia; medical trials in gentle cognitive impairment; Muscarinic agonists in Alzheimer's sickness; melancholy in dementia; melancholy in neurodegenerative issues and similar stipulations; Use of antipsychotic medications in dementia; Assessing competency in Alzheimer's disorder: remedy consent ability and monetary capability; administration of past due degree dementia; Index.
summary: The editors and participants deal with modern subject matters during this zone via comprehensively referenced chapters, in keeping with medical adventure and medical facts designed to stimulate dialogue of the place present remedy is heading
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Additional info for Alzheimer's disease and related disorders annual. / 2001
J Neurosci Res 2000; 60:804–810. Weller RO, Massey A, Kuo Y-M, Roher AE. Cerebral amyloid angiopathy: accumulation of Abeta in interstitial ﬂuid drainage pathways in Alzheimer’s disease. 93. 94. 95. 96. 97. Ann NY Acad Sci 2000; 903:110–117. Van Dorpe J, Smeijers L, Dewachter I, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons. Am J Pathol 2000; 157:1283–1298. Christie R, Yamada M, Moskowitz M, Hyman B. Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
Brain Pathol 1996; 6:179–195. 2. Verbeek MM, de Waal RMW, Vinters HV, eds. Cerebral amyloid angiopathy in Alzheimer’s disease and related disorders. Dordrecht: Kluwer Academic Publishers; 2000. 3. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. Alzheimer’s disease. Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 1998; 51(Suppl 1):S2–S17. 4. Selkoe DJ. Alzheimer’s disease: a central role for amyloid. J Neuropathol Exp Neurol 1994; 53:438–447. 5. Vinters HV.
Examples include medial temporal lobe atrophy, focal atrophy and vascular changes. 14–16 The technique reported by Jobst et al14 required 3 mm or thinner slices oriented parallel to the medial temporal lobe and skilful handling of the ruler or caliper. Unfortunately, others could not replicate their promising results. Using MRI, it became possible to study different areas within the medial temporal lobe, such as the hippocampus proper, parahippocampal gyrus, subiculum, entorhinal cortex and amygdala.